منابع مشابه
Tensegrity and mechanoregulation: from skeleton to cytoskeleton.
OBJECTIVE To elucidate how mechanical stresses that are applied to the whole organism are transmitted to individual cells and transduced into a biochemical response. DESIGN In this article, we describe fundamental design principles that are used to stabilize the musculoskeletal system at many different size scales and show that these design features are embodied in one particular form of arch...
متن کامل1 2 the Cytoskeleton Meets the Skeleton
2 THE CYTOSKELETON MEETS THE SKELETON 3 Omar Skalli, PhD 4 Department of Life Sciences, The University of Memphis, Memphis, TN 38152, USA. 5 Email: [email protected] 6 7 In the current issue, Moorer and colleagues put the limelight on synemin, which is one of the 70 8 intermediate filament (IF) proteins, by demonstrating that synemin knock-out mice exhibit a substantial 9 reduction in bone ma...
متن کاملFrom skeleton to cytoskeleton: osteocalcin transforms vascular fibroblasts to myofibroblasts via angiotensin II and Toll-like receptor 4.
RATIONALE The expression of osteocalcin is augmented in human atherosclerotic lesions. How osteocalcin triggers vascular pathogenesis and remodeling is unclear. OBJECTIVE To investigate whether osteocalcin promotes transformation of adventitial fibroblast to myofibroblasts and the molecular mechanism involved. METHODS AND RESULTS Immunohistochemistry indicated that osteocalcin was expressed...
متن کاملFrom skeleton branches to object parts
A method to decompose a 3D object into simple parts starting from its curve skeleton is described. Branches of the curve skeleton are classified as meaningful and non-meaningful by using the notion of zone of influence of the points where skeleton branches meet. Meaningful branches are associated to subsets of the object, which are obtained by subtracting from the input object suitably expanded...
متن کاملFrom Membrane to Cytoskeleton Enabling a Connection
by regulating all of these activities. In particular, families of proline-rich proteins, the WASP/SCAR and Ena/VASP families, play crucial roles in actin dynamics, and are Song Hu and Louis F. Reichardt* Department of Physiology Howard Hughes Medical Institute University of California believed to act, at least in part, by binding and thereby regulating Profilin’s activity (Figure 1). In additio...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2012
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.112.271361